Carbacyclin 是 PGI2 的类似物，为前列腺环素 (prostacyclin (PGI2)) 受体激动剂和血管舒张剂，能够有效抑制血小板聚集；Carbacyclin 同时可以通过 PPARδ 来诱导 CPT-1 mRNA 的表达，不依赖 IP 受体信号通路。
| 生物活性 |
Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 |
Carbacyclin is an agonist of prostacyclin (PGI2) receptor. Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro. Carbacyclin is a PGI2 analogue, activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes. |
|||||||||
| 体内研究 |
Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, dog or rabbit plasma. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart.
|
|||||||||
| 分子式 |
C21H34O4
|
|||||||||
| 分子量 |
350.49
|
|||||||||
| CAS号 |
69552-46-1
|
|||||||||
| 中文名称 |
卡巴环素
|
|||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
|||||||||
| 储存方式 |
|
纯度： 98%
咨询热线：
400-881-9290
Data Sheet
