MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) 是可透过血脑屏障的多巴胺 (dopamine) 神经毒素，MPTP 可用于诱导帕金森综合症模型。MPTP 是 MPP+ 的前体，可以诱导凋亡 (apoptosis)。
| 生物活性 |
MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a brain penetrant dopamine neurotoxin. MPTP can be used to induce Parkinson’s Disease model. MPTP, a precusor of MPP+, induces apoptosis. |
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| 体外研究 |
Pre treatment with 50 mM 4-phenylpyridine reduced the IC50 value of MPTP (50% concentration that inhibits seizure amplitude) from 53 mM to 18 mM and the IC50 value of d-tubulocurarine from 0.7 mM to 0.3 mM in mouse phrenic nerve diaphragm. |
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| 分子式 |
C12H15N
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| 分子量 |
173.25
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| CAS号 |
28289-54-5
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| 中文名称 |
1-甲基-4-苯基-1,2,3,6-四氢吡啶
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
2-8°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 溶解性数据 |
In Vitro:
DMSO: 50 mg/mL (288.60 mM; Need ultrasonic and warming) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
纯度： 98%
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Data Sheet
