KRASG12C IN-18 - CAS:2966924-24-1

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KRASG12C IN-18

目录号 : KM33213 CAS No. : 2966924-24-1

Data Sheet 产品使用指南

KRASG12C IN-18 是一种口服活性的 KRASG12C 共价抑制剂，可在 GDP 与 GMPPNP 结合状态下实现对 KRASG12C 的完全共价结合，并对 KRASG12C 及其耐药相关突变体（包括 KRASG12C/R68S）表现出显著的抗增殖活性，IC50 为低纳摩尔水平。KRASG12C IN-18 在 KRASG12C 驱动的实体瘤及 KRASG12C/R68S 异种移植模型中表现出显著的体内活性，可用于直肠腺癌研究。

规格	价格	是否有货
50mg	询价	In-stock
100mg	询价	In-stock
250mg	询价	In-stock

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生物活性

KRASG12C IN-18 is an orally active covalent KRASG12C inhibitor that achieves complete covalent engagement of KRASG12C in both GDP- and GMPPNP-bound states and displays strong antiproliferative activity against KRASG12C and resistance-associated variants, including KRASG12C/R68S, with low-nanomolar IC50 values.KRASG12C IN-18 exhibits marked in vivo efficacy in KRASG12C-driven solid tumor and KRASG12C/R68S xenograft models and can be used for colorectal cancer research.

分子式

C₃₇H₃₂F₄N₆O₂

分子量

668.68

CAS号

2966924-24-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation