| 生物活性 |
L-Asparagine-1,2,3,4-13C4 monohydrate is the 13C labeled labeled L-Asparagine monohydrate . L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
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| 分子式 |
13C4H8N2O3
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| 分子量 |
136.09
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| CAS号 |
768348-44-3
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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Data Sheet
