Lintuzumab (Synonyms:LINTUZUMAB ( 林妥珠单抗 );林妥珠单抗)
目录号 : KM36520 CAS No. : 166089-32-3
Lintuzumab (HUM-195) 是一种抗 CD33人源化单克隆抗体。Lintuzumab 可减少 AML 细胞产生 TNFα 诱导的促炎细胞因子和趋化因子。Lintuzumab 通过抗体依赖性细胞毒性 (ADCC) 和吞噬作用 (ADCP) 活性对 MDR 和 MDR+ AML 细胞系和原发性 AML 患者样本发挥肿瘤细胞杀伤效果。Lintuzumab 可提高肿瘤小鼠的存活率并减轻肿瘤负担。
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生物活性
Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice.
分子量
145.24 kDa
CAS号
166089-32-3
中文名称
Lintuzumab
运输条件
Shipping with dry ice.
储存方式
Store at -20˚C 
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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