Flotetuzumab (Synonyms:伏妥珠单抗)
目录号 : KM37585 CAS No. : 1664355-28-5 纯度 : 98%
Flotetuzumab (MGD006; S80880) 是一种双特异性 CD123/CD3 双亲和再靶向 (DART) 抗体。Flotetuzumab 通过同时结合靶细胞的 CD123 和效应 T 细胞的 CD3,而重新激活 T 细胞,导致 T 细胞介导的靶细胞的细胞毒性。Flotetuzumab 对小鼠中急性髓系白血病 (AML) 患者来源异种移植物 (PDX) 模型具有抑制效力。
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生物活性
Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule.Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML).
分子量
58.77 kDa
CAS号
1664355-28-5
中文名称
伏妥珠单抗
运输条件
Shipping with dry ice.
储存方式
Store at -20˚C 
The molarity calculator equation
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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