Bongkrekic acid 是一种由假单胞菌分泌的线粒体毒素 (mitochondrial toxin)。Bongkrekic acid 是线粒体腺嘌呤核苷酸 (ADP/ATP) 转位酶 (ANT) 的特异性配体而不是电子传递链的。Bongkrekic acid 必须通过线粒体内膜产生抑制 ADP/ATP 转运的作用。
| 生物活性 |
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport. |
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| 体外研究 |
Bongkrekic acid (0-50 μM; 48 hours) stimulated formazan formation in MDA-MB-231, MCF-7 and LTED cells with EC50 of 34.14 μM, >50 μM and 2.58 μM, respectively. |
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| 分子式 |
C28H38O7
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| 分子量 |
486.60
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| CAS号 |
11076-19-0
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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