Anti-IL11 Antibody (X203) (Synonyms:EnX203)
目录号 : KM32550 纯度 : 98%

Anti-IL11 Antibody (X203) (EnX203) 是一种人源的、抗人 IL-11 的 IgG1, κ 型抗体抑制剂。推荐同型对照:Human IgG1 kappa, Isotype Control。

规格 价格 是否有货 数量
1mg
In-stock
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生物活性

Anti-IL11 Antibody (X203) (EnX203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control.

体外研究

Anti-IL11 Antibody (X203) (20 μM; 48 h) can effectively inhibit downstream STAT3 phosphorylation induced by IL-11 in Bleomycin induced mouse nucleus pulposus cells.

 

Western Blot Analysis

Cell Line: Mouse nucleus pulposus (NP) cells treated with Bleomycin (40 μg/mL)
Concentration: 20 μM
Incubation Time: 48 hours
Result:
Effectively inhibited IL11–induced downstream STAT3 phosphorylation
体内研究

Anti-IL11 Antibody (X203) (20 mg/kg, intraperitoneal injection, twice a week starting from 6 weeks of age, lasting for 2.5 weeks) can improve renal function and prolong the lifespan of Alport syndrome (AS) mouse models.

 

Animal Model: Wild-type mice injected with BLM
Dosage: 20 mg/kg
Administration: i.p., alternate days from day 7 to 21 after BLM
Result: Showed no effect on overall survival.
Greatly reduced lung hydroxyproline content.
Reduced the expression of ECM-related genes.
Increased Mmp2/Timp1 ratio (a signature of preferential ECM remodeling) compared to control.
Markedly reduced ERK and SMAD activation whereas STAT3 phosphorylation remained elevated.
 
分子量
145.96 kDa
运输条件

Shipping with dry ice.

储存方式

Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2