KKL 顾客使用本产品发表的 0 篇科研文献

Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine . Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro.

Methyclothiazide (0-100 μM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from SHR, and the maximal vasoconstrictive effect of Norepinephrine and arginine vasopressin (AVP) is decreased by 59% and 32.3 %, respectively.
Methyclothiazide (0-100 μM) induces inhibitory effect on the contractile response to Norepinephrine is abolished by N-nitro-L-arginine (NOLA) but not indomethacin.
Methyclothiazide (100 μM) affects the vascular responses to extracellular Ca under high-K depolarizing conditions. It can reduce Ca contracture in a high-K, Ca-free solution. The maximal contracture is reduced by 90.4%.

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