Bucladesine sodium - CAS:16980-89-5

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Bucladesine sodium (Synonyms:布拉地新钠盐; Dibutyryl cAMP sodium salt; DBcAMP sodium salt)

目录号 : KM15094 CAS No. : 16980-89-5 纯度 : 99%

Data Sheet SDS 产品使用指南

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) 是一种稳定的环 AMP (cAMP) 类似物，也是一种选择性的 PKA 活化剂，可提高细胞内 cAMP 的水平。Bucladesine sodium salt 也是一种磷酸二酯 (PDE) 抑制剂。Bucladesine sodium salt 具有抗炎活性，可用于伤口愈合不良。

规格	价格	是否有货
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing.

体外研究

Both choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA increased approximately fourfold after treatment of PC12 cells with Bucladesine (dibutyryl cyclic AMP; dbcAMP). ChAT and PKA activity are also increased by Bucladesine.

体内研究

Intrahippocampal infusion of Bucladesine into the CA1 region (male Albino-Wistar rats) can cause an improvement in spatial memory in maze task. Bilateral infusion of 10 μM and 100 μM Bucladesine leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory). Bucladesine via activation of PKA and induction of cAMP/PKA pathway improved spatial memory retention.

分子式

C₁₈H₂₃N₅NaO₈P

分子量

491.37

CAS号

16980-89-5

中文名称

布拉地新钠盐；二丁酰环磷腺苷钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (203.51 mM; Need ultrasonic)

H₂O : ≥ 100 mg/mL (203.51 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0351 mL	10.1756 mL	20.3513 mL
5 mM	0.4070 mL	2.0351 mL	4.0703 mL
10 mM	0.2035 mL	1.0176 mL	2.0351 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

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