Ustekinumab 是一种抗 IL-12/IL-23 的人源单克隆 IgG1κ 抗体。
| 生物活性 |
Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody. |
|---|---|
| 体外研究 |
Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0). |
| 分子式 |
C14H18N5O2Cl3
|
| 分子量 |
145.63 kDa
|
| CAS号 |
815610-63-0
|
| 中文名称 |
尤特克单抗
|
| 运输条件 |
Shipping with dry ice. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 临床试验 |
|
| 科研文献 |
纯度： 98%
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Data Sheet
