Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM.
体外研究
Pep2-8 binds to C-terminally truncated PCSK9.
Pep2-8 restored LDL uptake of PCSK9-treated HepG2 cells to about 90% of control activity at a concentration of 50 μM.
Cell Viability Assay
Cell Line:
HepG2 cell.
Concentration:
15 μg/mL.
Incubation Time:
4 h.
Result:
Inhibited PCSK9 activity.
分子式
C83H113N17O24
分子量
1715.85
CAS号
1541011-97-5
运输条件
Room temperature in continental US; may vary elsewhere.