Antisauvagine-30 TFA - KKL Med Inc.

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Antisauvagine-30 TFA

目录号 : KM17494 纯度 : 98%

Data Sheet 产品使用指南

Antisauvagine-30 TFA (aSvg-30 TFA) 是有效的、高度选择性的、竞争性的 CRF₂ 受体的多肽拮抗剂。Antisauvagine-30 TFA 对 mCRFR2β 和 CRFR1 的 K_d 值分别为1.4 nM 和150 nM。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
Velufenacin In-stock

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生物活性

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF₂ receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a K_d of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

体外研究

Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice.

体内研究

Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice.
Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect.

Animal Model:	Nine-week-old male BALB/c mice.
Dosage:	400 ng/0.5 μl per mouse.
Administration:	Administered bilaterally by a microinjector (intrahippocampal (i.h.) injection).
Result:	Prevented the stress-induced enhancement of fear conditioning.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 25 mg/mL (6.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2657 mL	1.3283 mL	2.6566 mL
5 mM	0.0531 mL	0.2657 mL	0.5313 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%