Tocilizumab - CAS:375823-41-9

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Tocilizumab (Synonyms:托珠单抗)

目录号 : KM17535 CAS No. : 375823-41-9 纯度 : 98%

Data Sheet 产品使用指南

Tocilizumab (Anti-Human IL6R, Humanized Antibody) 是一种抗人白细胞介素-6 受体 (IL-6R) 的中和抗体，可阻止 IL-6 与 IL-6R 的结合，从而抑制经典和反式信号。Tocilizumab 可用于类风湿性关节炎的相关研究。Tocilizumab 在重症 COVID-19 冠状病毒病方面的研究效果显著。

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1mg		In-stock
5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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Other Forms of Rapamycin:

Crebankitug In-stock
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生物活性

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).

体外研究

Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-100 ng/mL; 24 hours, 48 hours) inhibits the cell proliferation (growth rate) in a dose-dependent manner, growth rate by HACM is reduced almost completely by 100 ng/mL tocilizumab.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (0.001-10,000 μg/ml; 2 days) inhibits Ba/F3-gp130-IL-6R cell proliferation stimulated with hIL-6 with an IC₅₀ of 13.5 ng/ml.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1 μM; 6 hours) reduces the phosphorylation of STAT3 in vitro consistent with in vivo SAS cells.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-5 μM; 24 hours) significantly reduces VEGF mRNA expression in SAS cells with serum-free medium.

Cell Proliferation Assay

Cell Line:	Human-derived HARA-B cells
Concentration:	1 ng/mL, 10 ng/mL, and 100 ng/mL
Incubation Time:	24 hours, 48 hours
Result:	Inhibited the IL-6R expressed on human-derived HARA-B cells.

Cell Cytotoxicity Assay

Cell Line:	Ba/F3-gp130-IL-6R cells
Concentration:	0.001–10000 μg/ml
Incubation Time:	2 days
Result:	Inhibited Ba/F3-gp130-IL-6R cell proliferation.

Western Blot Analysis

Cell Line:	SAS cells
Concentration:	1 μM
Incubation Time:	6 hours
Result:	Reduced the phosphorylation of STAT3.

RT-PCR

Cell Line:	SAS cells
Concentration:	1-5 μM
Incubation Time:	24 hours
Result:	Reduced VEGF mRNA expression.

体内研究

Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intravenous injection; 1.0 mg/100 μL; twice a week, three weeks) decreases the volume of each metastatic focus in tocilizumab-injected mouse brains.
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intraperitoneal injection;100 μg/mL, every 48 hours; 20days) suppresses OSCC progression and suppresses Tumor Angiogenesis.

Animal Model:	A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice
Dosage:	1.0 mg/100 μL
Administration:	Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks
Result:	Led the volume of each metastatic focus significantly smaller.

Animal Model:	SCID mice with SAS cells
Dosage:	100 μg/mL
Administration:	Intraperitoneal injection;100 μg/mL; every 48 hours; 20days
Result:	Suppressed the growth of advanced tumors.

分子量

145.2 kDa

CAS号

375823-41-9

中文名称

托珠单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 3 篇科研文献

The molarity calculator equation

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