Mepenzolate bromide - CAS:76-90-4

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Mepenzolate bromide (Synonyms:溴美喷酯；溴化甲哌佐酯)

目录号 : KM18002 CAS No. : 76-90-4 纯度 : 98%

Data Sheet 产品使用指南

Mepenzolate bromide 是一种有效的，具有口服活性的毒蕈碱受体拮抗剂，对 hM2R 和 hM3R 的 K_i 分别为 0.68 和 2.6 nM。Mepenzolate bromide 可用于抑制与肠易激综合征相关的胃肠道过度运动。Mepenzolate bromide 是一种 GPR109A 抑制剂.

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100mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

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生物活性

Mepenzolate bromide is an orally administered muscarinic receptor antagonist with K_is of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome.Mepenzolate bromide is a GPR109A inhibitor.

体外研究

Mepenzolate not only exerts an anti-inflammatory effect via a muscarinic receptor-independent mechanism, but also a bronchodilatory effect via a muscarinic receptor-dependent mechanism. Mepenzolate is a subtype-non-specific muscarinic antagonist whose bronchodilatory effect and inhibitory effect on intestinal motility can be explained by its antagonistic action on M3R.

体内研究

Mepenzolate bromide, a GPR109A receptor blocker, abolishes the beneficial effects of niacin on body weight, colon wet weight as well as colonic levels of myeloperoxidase (MPO) and VEGF.
Mepenzolate bromide is a muscarinic antagonist. Intratracheal administration or inhalation of Mepenzolate bromide decreases the severity of elastase-induced airspace enlargement and respiratory dysfunction. Mepenzolate bromide may be an effective therapeutic for the treatment of chronic obstructive pulmonary disease (COPD) due to its anti-inflammatory and bronchodilatory activities.

Animal Model:	Adult male Wistar rats, weighing 150-200 g
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection
Result:	Abolished the protective effect of niacin against iodoacetamide-induced rise in colon wet weight as well as the colonic levels of both MPO and VEGF.

Animal Model:	ICR mice (4-6 weeks old, male) and DBA/2 mice (5 weeks old, female)
Dosage:	0.04, 0.38, 3.8, 38 μg/kg; 45.2 and 226 μg per chamber
Administration:	"0.04, 0.38, 3.8, 38 μg/kg administered intratracheally once daily for 14 days 45.2 and 226 μg per chamber by inhalation once daily for 14 days"
Result:	The simultaneous daily intratracheal administration suppressed this enlargement in a dose-dependent manner. The inhalation route was similar to those observed with the intratracheal mode of administration.

分子式

C₂₁H₂₆BrNO₃

分子量

420.34

CAS号

76-90-4

中文名称

溴美喷酯；溴化甲哌佐酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 35 mg/mL (83.27 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3790 mL	11.8951 mL	23.7903 mL
5 mM	0.4758 mL	2.3790 mL	4.7581 mL
10 mM	0.2379 mL	1.1895 mL	2.3790 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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