ARL67156 trisodium salt hydrate

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ARL67156 trisodium salt hydrate (Synonyms:FPL 67156 trisodium hydrate)

目录号 : KM2494 纯度 : 98%

Data Sheet 产品使用指南

ARL67156 trisodium salt hydrate 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium salt hydrate 是弱的竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，K_i 分别为 11，18 和 12 μM。ARL67156 trisodium salt hydrate 可预防体内主动脉瓣钙化。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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生物活性

ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase. ARL67156 trisodium salt hydrate is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12 μM, respectively. ARL67156 trisodium salt hydrate prevents in vivo the development of calcific aortic valve disease.

体外研究

ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.

体内研究

Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg).

Animal Model:	C57BL/6 mice
Dosage:	2 mg/kg
Administration:	Pre-treated (i.p.) 1 h before administration of FBP (100 mg/kg)
Result:	Completely prevented the increase of serum adenosine concentration induced by FBP.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H2O : 16.9 mg/mL (20.25 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.1982 mL	5.9908 mL	11.9816 mL
5 mM	0.2396 mL	1.1982 mL	2.3963 mL
10 mM	0.1198 mL	0.5991 mL	1.1982 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献