Valproic acid sodium salt - CAS:1069-66-5

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Valproic acid sodium salt (Synonyms:丙戊酸钠; Sodium Valproate)

目录号 : KM2663 CAS No. : 1069-66-5 纯度 : ≥97%

Data Sheet SDS 产品使用指南

Valproic acid sodium salt (Sodium Valproate) 是一种 HDAC 抑制剂，IC₅₀ 值为 0.5-2 mM，抑制 HDAC1 的活性，(IC₅₀，400 μM)，同时可诱导 HDAC2 的降解。Valproic acid sodium salt 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid sodium salt 可用于癫痫、双相情感障碍和偏头痛等的研究。

规格	价格	是否有货
500mg		In-stock
1g		In-stock
5g		In-stock
25g		In-stock
50g	询价	In-stock

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生物活性

Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

体外研究

Valproic acid sodium salt (Sodium Valproate) inhibits the growth dose- and time-dependently with an IC₅₀ of appr 10 and 4 mM at 24 and 72 h, respectively. Valproic acid sodium salt significantly attenuates the activities of total, cytosol and nuclear HDACs. Valproic acid sodium salt increases the form of acetylated histone 3 in HeLa cells. Valproic acid sodium salt (1-3 mM) induces a G1 phase arrest, while 10 mM Valproic acid sodium salt significantly induces a G2/M phase arrest of cell cycle in HeLa cells. In addition, Valproic acid sodium salt increases the percentage of sub-G1 cells in HeLa cells in a dose-dependent manner at 24 h.
Valproic acid sodium salt inhibits the mRNA and protein expression of VEGF, VEGFR2 and bFGF. Valproic acid sodium salt inhibits the protein expression of HDAC1, increases histone H3 acetylation, and enhances the accumulation of hyperacetylated histone H3 on VEGF promoters.
Valproic acid sodium salt treatment results in increased levels of phosphorylated AMPK/ACC in primary mouse hepatocytes. Phosphorylation of ACC following Valproic acid sodium salt treatment is AMPK-dependent. Valproic acid sodium salt inhibits the deacetylase activity of both mouse liver nuclear extracts and human recombinant HDAC1 while of the metabolites of Valproic acid, only 2-ene-Valproic acid and 4-ene-Valproic acid diminish deacetylase activity.

体内研究

Valproic acid sodium salt (Sodium Valproate; 500 mg/kg, i.p.) inhibits the tumor growth and angiogenesisin the mice transplanted with Kasumi-1 cells. The IR rate in the Valproic acid sodium salt group is 57.25% at the end of the experiment.
Valproic acid sodium salt (350 mg/kg, i.p.) demonstrates more social investigation and play fighting than control animals.

分子式

C₈H₁₅NaO₂

分子量

166.19

CAS号

1069-66-5

中文名称

丙戊酸钠；丙戊酸钠盐；定百痉；癫扑净；抗癫灵；敌白痉；2-丙基戊酸钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 125 mg/mL (752.15 mM; Need ultrasonic)

DMSO : 10 mg/mL (60.17 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.0172 mL	30.0860 mL	60.1721 mL
5 mM	1.2034 mL	6.0172 mL	12.0344 mL
10 mM	0.6017 mL	3.0086 mL	6.0172 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS

Solubility: 100 mg/mL (601.72 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： Saline

Solubility: 50 mg/mL (300.86 mM); Clear solution; Need ultrasonic