15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester - CAS:130273-87-9

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15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (Synonyms:Bimatoprost isopropyl ester)

目录号 : KCM10970 CAS No. : 130273-87-9 纯度 : ≥98%

Data Sheet 产品使用指南

15(R)-17-phenyl trinor Prostaglandin F isopropyl ester (15(R)-17-phenyl trinor PGF isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC values for the free acid forms of 15(S)-17-phenyl trinor PGF and 15(R)-17-phenyl trinor PGF were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(R)-17-phenyl trinor PGF caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

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1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg		In-stock

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15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC₅₀ values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

分子式

C₂₆H₃₈O₅

分子量

430.6

CAS号

130273-87-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

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