2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC value of 0.33 µM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin . It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC = 16.41 µM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (ICs = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (ICs = 99.6 and >100 µM, respectively). However, it also decreases viability of RCC10 VHL and RCC10 VHL cells (ICs = 5.04 and 0.96 µM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL cells in a concentration-dependent manner.