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Argatroban (Synonyms:阿加曲班;(2R,4R)-4-甲基-1-[N-[(3-甲基-1,2,3,4-四氢-8-喹啉基)磺酰]-L-精氨酰]-2-哌啶甲酸;(2R,4R)-1-[(2S)-5-(氨基亚氨甲基)氨基-1-氧代-2-[(3-甲基-1,2,3,4-四氢喹啉-8-基)磺酰胺基]戊烷]-4-甲基哌啶-2-甲酸;L-天冬氨酸二苄酯;阿加曲班标准品;阿加曲班杂质;(2R,4R)-1-[5-[(氨基亚氨基甲基)氨基]-1-氧代-2-[[(1,2,3,4-四氢-3-甲基-8-喹啉基)磺酰基]氨基]戊基]-4-甲基-2-哌啶羧酸;阿各卓泮)
目录号 : KCM15117 CAS No. : 74863-84-6 纯度 : ≥95%
Data Sheet SDS 产品使用指南
Argatroban is a reversible inhibitor of thrombin (ICs = 0.01 and 0.09 µM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Ks = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC value of 0.077 µM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
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分子式
C23H36N6O5S
分子量
508.6
CAS号
74863-84-6
中文名称
阿加曲班
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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