Aspulvinone O
目录号 : KCM15737
CAS No. : 914071-54-8
纯度 : ≥95%
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC = 11.6 µM). Aspulvinone O inhibits aspartate transaminase 1 (GOT1; K = 3.32 µM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (ICs = 20.54-26.8 µM). It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model.
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| 分子式 |
C27H28O6
|
| 分子量 |
448.50762
|
| CAS号 |
914071-54-8
|
| 中文名称 |
Aspulvinone O
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|