Zoledronic acid
(Synonyms:唑来膦酸;唑仑膦酸;1-羟基-2-(咪唑-1-基)-亚乙基-1,1-二磷酸;唑来磷酸;[1-羟基-2-(1H-咪唑-1-基)亚乙基]二磷酸一水合物;唑来膦酸一水合物;唑来膦酸盐;环戊基乙酰氯;唑来膦酸 USP标准品;唑来膦酸标准品;唑仑膦酸一水物)
目录号 : KF1120
CAS No. : 118072-93-8
纯度 : 98%
Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures). The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast apoptosis and blockage of osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid is a clinically useful drug for treatment of osteoporosis, hypercalcemia of malignancy(HCM), multiple myeloma and bone metastases from solid tumors. It has also been investigated as an antitumor agent and showing efficacy as an adjuvant therapy in several cancers.
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| 分子式 |
C5H10N2O7P2
|
| 分子量 |
272.09
|
| CAS号 |
118072-93-8
|
| 中文名称 |
唑来膦酸
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|
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