17-ODYA 是一种 CYP450 ω-羟化酶 (CYP450 ω-hydroxylase) 抑制剂。17-ODYA 是与花生四烯酸孵育的大鼠肾皮质微粒体形成 20-HETE、epoxyeicosatrienoic acids 和 dihydroxyeicosatrienoic acids 的有效抑制剂 (IC50<100 nM)。17-ODYA 减弱异丙肾上腺素 (ISO) 诱导的培养心肌细胞凋亡和坏死。
| 生物活性 |
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes. |
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| 体内研究 |
Infusion of 17-ODYA (16.5 nmol/min) directly into the renal cortical interstitium of rats produced a diuresis and a natriuresis which were associated with an increase in renal papillary blood flow in the absence of changes in renal blood flow, cortical blood flow or glomerular filtration rate.
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| 分子式 |
C18H32O2
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| 分子量 |
280.45
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| CAS号 |
34450-18-5
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： ≥95%
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