ER-819762 is a highly selective, and orally available antagonist of the prostaglandin EP4 receptor (IC50 value of 70 nM). Oral administration of ER-819762 to DBA/1 mice can effectively suppress disease in collagen-induced arthritis (CIA) or glucose-6-phosphate isomerase (GPI)-induced arthritis models. ER-819762 was also effective in treating chronic inflammatory pain in a rat model.