CV-6209 (chloride) - CAS:100488-87-7

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CV-6209 (chloride) (Synonyms:4-{[(3-氟苯基)氨基]甲基}-4-羟基哌啶-1-甲酸苄酯)

目录号 : KCM10021 CAS No. : 100488-87-7 纯度 : ≥95%

Data Sheet SDS 产品使用指南

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC values of 75 and 170 nM, respectively. It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol . CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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生物活性

CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats[1].

体外研究

CV-6209 inhibits [3H]serotonin release from rabbit platelets stimulated with PAF (30 nM)[1] .

CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen[1] .

CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs[1].

体内研究

CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED50=0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol[1] .

CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice[3] .

分子式

C₃₄H₆₀N₃O₆^.Cl

分子量

606.85682

CAS号

100488-87-7

中文名称

4-{[(3-氟苯基)氨基]甲基}-4-羟基哌啶-1-甲酸苄酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 100 mg/mL (155.69 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5569 mL	7.7844 mL	15.5688 mL
5 mM	0.3114 mL	1.5569 mL	3.1138 mL
10 mM	0.1557 mL	0.7784 mL	1.5569 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%