Dabigatran Acyl-β-D-Glucuronide
(Synonyms:达比加群酰基 - D-葡萄糖醛酸标准品;5-(1-氨基环己基)-1,3,4-噻二唑-2-胺二盐酸盐;达比加群酰基-β-D-葡糖苷酸;达比加群酰基Β维葡糖苷酸;N-[[2-[[[4-(氨基亚胺甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BETA-丙氨酸 BETA-D-吡喃葡糖酸基酯)
目录号 : KCM10059
CAS No. : 1015167-40-4
纯度 : ≥90%
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.
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| 分子式 |
C31H33N7O9
|
| 分子量 |
647.6355
|
| CAS号 |
1015167-40-4
|
| 中文名称 |
达比加群酰基 - D-葡萄糖醛酸标准品
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|