(E/Z)-Endoxifen
(Synonyms:N-去甲基-4-羟基-;(Z)-4-(1-(4-(2-(甲氨基)乙氧基)苯基)-2-苯基丁-1-烯基)苯酚;4-[(E)-1-[4-(2-甲基氨基乙氧基)苯基]-2-苯基丁-1-烯基]苯酚;双氯酚甲酯;4-[1-[4-[2-(甲基氨基)乙氧基]苯基]-2-苯基-1-丁烯-1-基]苯酚)
目录号 : KCM10306
CAS No. : 110025-28-0
纯度 : 90%
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.
Other Forms of Rapamycin:
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| 分子式 |
C25H27NO2
|
| 分子量 |
373.5
|
| CAS号 |
110025-28-0
|
| 中文名称 |
双氯酚甲酯
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|