(E/Z)-Endoxifen (Synonyms:N-去甲基-4-羟基-;(Z)-4-(1-(4-(2-(甲氨基)乙氧基)苯基)-2-苯基丁-1-烯基)苯酚;4-[(E)-1-[4-(2-甲基氨基乙氧基)苯基]-2-苯基丁-1-烯基]苯酚;双氯酚甲酯;4-[1-[4-[2-(甲基氨基)乙氧基]苯基]-2-苯基-1-丁烯-1-基]苯酚)
目录号 : KCM10306 CAS No. : 110025-28-0 纯度 : 90%
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.
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分子式
C25H27NO2
分子量
373.5
CAS号
110025-28-0
中文名称
双氯酚甲酯
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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