URB447
目录号 : KCM10391
CAS No. : 1132922-57-6
纯度 : ≥98%
URB447 is a cannabinoid 1 (CB) receptor antagonist and CB receptor agonist. It inhibits the binding of the CB receptor agonist [H]-WIN 55,212-2 to CHO-K1 cells expressing the human CB receptor or rat cerebellar membranes (ICs = 41 and 313 nM, respectively). URB447 (20 mg/kg) reduces food intake and weight gain in ob/ob mice and reverses (R)-methanandamide-induced analgesia in mice. It decreases infarct volume and demyelination in a neonate rat model of hypoxia-ischemia-induced brain injury when administered at a dose of 1 mg/kg.
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| 分子式 |
C25H21ClN2O
|
| 分子量 |
400.9
|
| CAS号 |
1132922-57-6
|
| 中文名称 |
[4-amino-1-[(4-chlorophenyl)methyl]-2-methyl-5-phenylpyrrol-3-yl]-phenylmethanone
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|