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BML-278 (Synonyms:DIETHYL 1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXI APPTEC")
目录号 : KCM10626 CAS No. : 120533-76-8 纯度 : ≥95%
Data Sheet 产品使用指南
BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC value (effective concentration able to increase the enzyme by 150%) of 1 µM. It less potently activates SIRT2 and SIRT3 (ECs = 25 and 50 µM, respectively). BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA , a histone deacetylase inhibitor. It arrests cell cycling at the G/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.
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分子式
C24H25NO4
分子量
391.5
CAS号
120533-76-8
中文名称
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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