AKP-11 - CAS:1220973-37-4

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AKP-11 (Synonyms:S1P1 agonist 1)

目录号 : KCM10725 CAS No. : 1220973-37-4 纯度 : ≥95%

Data Sheet 产品使用指南

AKP-11 is an agonist of sphingosine-1-phosphate receptor 1 (S1P) with an EC value of 0.047 μM for [S]GTPγS binding to CHO-K1 cell membranes expressing the human receptor. It decreases surface expression of S1P and increases phosphorylation of Akt and ERK in CHO cells expressing S1P-HA when used at a concentration of 100 nM. AKP-11 (1.3 and 3 mg/kg) reduces protein levels of IFN-γ and IL-17 in spinal cord tissue and decreases disease severity in a rat model of experimental autoimmune encephalomyelitis (EAE). It decreases peripheral counts of total lymphocytes and total, CD4, CD8, and CD26L T cells in an EAE rat model, as well as in healthy control animals, when administered at a dose of 1.3 mg/kg.

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg	询价	In-stock
10 mM * 1 mL in DMSO	询价	In-stock

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生物活性

AKP-11 （S1P1 Agonist 1） is a S1P1 agonist with immunomodulatory activities.

体外研究

AKP-11 （S1P1 Agonist 1） binds to S1P1 is internalized and activates intracellular AKT and ERKs cellular signaling pathways.

AKP-11 （S1P1 Agonist 1） mediated S1P1 downregulation is independent of sphingosine kinase activity indicating it to be a direct agonist of S1P1.

AKP-11 （S1P1 Agonist 1） decreases cell surface expression of S1P1 in in vitro cell culture mode.

体内研究

AKP-11 （S1P1 Agonist 1） (1.3mg/kg) attenuates EAE disease. EAE is the animal model of multiple sclerosis which is extensively used for investigating clinical studies for multiple sclerosis drugs. AKP-11 （S1P1 Agonist 1） treatment reduces peripheral total blood lymphocyte and T lymphocyte counts significantly. The reduction in total lymphocytes and T cells are 48% and 41% in AKP11 treated animals, respectively. The reduction in the CD4+ and CD8+ T cell populations are 41% and 40% in S1P1 Agonist 1 treated animals, respectively. AKP-11 （S1P1 Agonist 1）treatment reduces CNS infiltration of T cells and Cytokines and enhances neuroprotection. AKP-11 （S1P1 Agonist 1） treatment has little effect on the heart rate of animals. The decrease in blood pressure is also smaller with S1P1 Agonist 1 treatment as compared animals treated with FTY720.

分子式

C₂₂H₂₂ClN₃O₅

分子量

443.88

CAS号

1220973-37-4

中文名称

AKP-11

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: ≥ 125 mg/mL (281.61 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2529 mL	11.2643 mL	22.5286 mL
5 mM	0.4506 mL	2.2529 mL	4.5057 mL
10 mM	0.2253 mL	1.1264 mL	2.2529 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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