ICI 216140 - CAS:124001-41-8

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ICI 216140

目录号 : KCM10780 CAS No. : 124001-41-8 纯度 : ≥95%

Data Sheet SDS 产品使用指南

Bombesin is a peptide, originally isolated from the skin of the European fire-bellied toad, with pressor and sympathoexcitatory activity. Its three receptors are distributed throughout the central and peripheral nervous system and are involved in gastric acid secretion, emotional response, temperature control, learning, and memory. Neuromedin B and gastrin-releasing peptide (GRP) are mammalian homologs of bombesin. ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC = 2 nM in vitro). At 2 mg/kg, it can reduce bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been shown to attenuate bombesin-stimulated increases in blood pressure in rats.

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock
5mg		In-stock

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生物活性

ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin stimulated pancreatic amylase secretion and attenuates Bombesin stimulated increases in blood pressure.

分子式

C₄₅H₆₅N₁₃O₈

分子量

916.1

CAS号

124001-41-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: 50 mg/mL (54.58 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0916 mL	5.4580 mL	10.9161 mL
5 mM	0.2183 mL	1.0916 mL	2.1832 mL
10 mM	0.1092 mL	0.5458 mL	1.0916 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%