(±)-Felodipine-d5 - CAS:1242281-38-4

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(±)-Felodipine-d5 (Synonyms:非洛地平-d5)

目录号 : KCM10792 CAS No. : 1242281-38-4 纯度 : 98%

Data Sheet 产品使用指南

(±)-Felodipine-d is intended for use as an internal standard for the quantification of felodipine by GC- or LC-MS. Felodipine is an inhibitor of L-type calcium channels. It induces relaxation of precontracted isolated porcine coronary artery segments (EC = 0.15 nM), which highly express L-type calcium channels. Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Ca3.2 channel (IC = 6.8 µM). Felodipine preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (ICs = 33.9 and 3,981 nM, respectively). It decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation when administered intravenously at doses of 30 and 100 nmol/kg.

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1mg		In-stock

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生物活性

Felodipine-d5 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.

分子式

C₁₈H₁₄Cl₂D₅NO₄

分子量

389.2835

CAS号

1242281-38-4

中文名称

非洛地平-d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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