Tolvaptan-d is intended for use as an internal standard for the quantification of tolvaptan by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V receptor antagonist (IC = 3 nM for rat receptor) and a diuretic agent. It is selective for V over V receptors (IC = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction. Formulations containing tolvaptan have been used to treat hyponatremia.
Tolvaptan-d7 is the deuterium labeled Tolvaptan. Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation.
分子式
C26H18ClD7N2O3
分子量
455.9835
CAS号
1246818-18-7
中文名称
托伐普坦 d7
运输条件
Room temperature in continental US; may vary elsewhere.