4-Quinolone-3-Carboxamide CB2 Ligand
目录号 : KCM11010 CAS No. : 1314230-69-7 纯度 : ≥98%
Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB and peripheral CB receptors. The CB receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB ligand is a selective, high-affinity ligand of the CB receptor, displaying a K value of 0.6 nM (K >10,000 nM for CB) in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB antagonist AM630 , which suggests 4-quinolone-3-carboxamide CB ligand may behave as an inverse agonist.
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生物活性

4-Quinolone-3-Carboxamide CB2 Ligand is a ligand of CB2 receptor with antagonist effect.

分子式
C26H34N2O3
分子量
422.6
CAS号
1314230-69-7
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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