4-Quinolone-3-Carboxamide Furan CB2 Agonist - CAS:1314230-75-5

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4-Quinolone-3-Carboxamide Furan CB2 Agonist (Synonyms:CB2 receptor agonist 2)

目录号 : KCM11011 CAS No. : 1314230-75-5 纯度 : ≥98%

Data Sheet 产品使用指南

Agonists of the peripheral cannabinoid (CB) receptor CB may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis. 4-Quinolone-3-carboxamide Furan CB Agonist is a high-affinity ligand of CB (K = 8.5 nM) with little affinity for CB (K >10,000 nM). This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB-selective antagonist, AM630 .

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

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生物活性

4-Quinolone-3-Carboxamide Furan CB2 Agonist is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. 4-Quinolone-3-Carboxamide Furan CB2 Agonist has high affinity and selectivity for CB2.

体外研究

4-Quinolone-3-Carboxamide Furan CB2 Agonist (1 μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells.

Cell Proliferation Assay

Cell Line:	Hep-G2 (Human hepatoblastoma) cells
Concentration:	1 μM
Incubation Time:	72 hours
Result:	Exhibited very low or no cytotoxicity to Hep-G2 cells.

体内研究

4-Quinolone-3-Carboxamide Furan CB2 Agonist (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist) .

Animal Model:

Formalin injection induces a biphasic stereotypical nocifensive behavior in mice

Dosage:

Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour

Administration:

Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)

Result:

Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.

分子式

C₃₀H₃₆N₂O₄

分子量

488.62

CAS号

1314230-75-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

Ethanol : 30 mg/mL (61.40 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0466 mL	10.2329 mL	20.4658 mL
5 mM	0.4093 mL	2.0466 mL	4.0932 mL
10 mM	0.2047 mL	1.0233 mL	2.0466 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

CB2

8.5 nM (Ki)

纯度： ≥98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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