(−)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB receptor, blocking both the stimulating action of CP 55,940 (pA = 6.1) and the inverse agonism of SR 144528 (pEC = 5.3). (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ-THC on rat cerebellar membranes, which presumably express the CB receptor. (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT and muscarinic M receptors but has no effect on several other G protein-coupled receptors.
| 生物活性 |
(−)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB receptor, blocking both the stimulating action of CP 55,940 (pA = 6.1) and the inverse agonism of SR 144528 (pEC = 5.3). (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ-THC on rat cerebellar membranes, which presumably express the CB receptor. (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT and muscarinic M receptors but has no effect on several other G protein-coupled receptors. |
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| 分子式 |
C27H26N2O3.CH3SO3H
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| 分子量 |
522.61
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| CAS号 |
131543-25-4
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： ≥98%
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