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Dantrolene (sodium salt) (Synonyms:丹曲林钠;1-[[[5-(4-硝基苯)-2-呋喃亚甲基]氨基]-2,4-咪唑烷二酮钠盐;丹曲洛林钠盐水合物;Dantrolene Sodium Salt Hydrate 丹曲洛林钠盐水合物;丹曲林 钠盐;丹曲林钠（骨骼肌松弛药）;单曲林钠;1-[[[5-(4-硝基苯)-2-呋喃基]亚甲基氨基]-2,4-咪唑啉二酮 钠盐;丹曲林钠(FDA);丹曲林钠(标准品);4-咪唑啉二酮 钠盐;1-[[[5-(4-硝基苯)-2-呋喃基]亚甲基氨基]-2)
目录号 : KCM11497 CAS No. : 14663-23-1 纯度 : ≥98%
Data Sheet SDS 产品使用指南
Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC = 0.3 µM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with K values of 0.3 and 0.09 µM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC values of 0.42 and 0.19 µM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC = 3 µg/ml) and MHS pigs (ED = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.
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分子式
C14H9N4O5.Na
分子量
336.2
CAS号
14663-23-1
中文名称
丹曲林钠
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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