8-(3-Chlorostyryl)caffeine - CAS:147700-11-6

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8-(3-Chlorostyryl)caffeine (Synonyms:8-[(E)-2-(3-氯苯基)乙烯基]-1,3,7-三甲基-3,7-二氢-1H-嘌呤-2,6-二酮;(E)-CSC)

目录号 : KCM11515 CAS No. : 147700-11-6 纯度 : ≥98%

Data Sheet 产品使用指南

8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A receptor antagonist (K = 54 nM). It is selective for adenosine A over A receptors (K = 28 µM). CSC reverses locomotor depression induced by the adenosine A agonist APEC in mice (ED = 16 µg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A receptor levels induced by L-DOPA in a rat model of Parkinson’s disease induced by 6-OHDA . It also inhibits monoamine oxidase B (MAO-B; K = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A mice.

规格	价格	是否有货	数量
10mg		In-stock
25mg		In-stock
50mg		In-stock
10 mM * 1 mL in DMSO		In-stock

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生物活性

8-(3-Chlorostyryl)caffeine is a MAO-B inhibitor and adenosine A_2A receptor antagonist. 8-(3-Chlorostyryl)caffeine inhibits the activity of monoamine oxidase B through a pathway independent of adenosine A_2A receptor antagonism. 8-(3-Chlorostyryl)caffeine can be used in research related to Parkinson's disease.

体外研究

8- (3-Chlorostyryl) caffeine (different inhibitor concentrations; When MMTP was used as a substrate for 15 minutes, MAO-B in baboon liver mitochondria was effectively and competitively inhibited, with a Ki value of 128 nM [1].

8- (3-Chlorostyryl) caffeine (different inhibitor concentrations; When using benzylamine as a substrate for 8 minutes, it can effectively and competitively inhibit monoamine oxidase B (MAO-B) in baboon liver mitochondria, with a Ki value of 148 nM [1].

分子式

C₁₆H₁₅ClN₄O₂

分子量

330.77

CAS号

147700-11-6

中文名称

8-[(E)-2-(3-氯苯基)乙烯基]-1,3,7-三甲基-3,7-二氢-1H-嘌呤-2,6-二酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 8.27 mg/mL (25.00 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0232 mL	15.1162 mL	30.2325 mL
5 mM	0.6046 mL	3.0232 mL	6.0465 mL
10 mM	0.3023 mL	1.5116 mL	3.0232 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%