1',4"-Sophorolactone 6',6"-diacetate - CAS:148409-20-5

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1',4"-Sophorolactone 6',6"-diacetate (Synonyms:槐糖脂;Lactonic sophorolipid)

目录号 : KCM11530 CAS No. : 148409-20-5 纯度 : ≥95%

Data Sheet 产品使用指南

1',4"-Sophorolactone 6',6"-diacetate is a major glycolipid produced from fermentation of sugar by yeasts including C. bombicola. This lactone form of sophorolipid has found use as a biosurfactant, possessing lower surface tension compared to the acid form of sophorolipids.

规格	价格	是否有货	数量
500mg		In-stock
1g		In-stock

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生物活性

1',4"-Sophorolactone 6',6"-diacetate is an apoptosis inducer and antimicrobial surfactant with antitumor activity. Lactonic sophorolipid regulates Bax/Bcl-gene expression through caspase-3/9 and induces apoptosis in tumor cells. 1',4"-Sophorolactone 6',6"-diacetate can disrupt cell membrane permeability and exert antibacterial effects (MIC for oral pathogens is 100-400 μg/mL). 1',4"-Sophorolactone 6',6"-diacetate promotes mitochondrial membrane potential depolarization, activates the intrinsic apoptotic pathway, and can synergize with antibiotics to enhance the antibacterial effect. 1',4"-Sophorolactone 6',6"-diacetate can be used in liver cancer research and the development of oral hygiene antibacterial agents.

体外研究

1',4"-Sophorolactone 6',6"-diacetate inhibits HepG2 cell viability with an IC₅₀ of 25 μg/mL (24 h) and induces apoptosis, accompanied by an increase in Caspase-3/9 enzyme activity and upregulation of Bax/Bcl-2 gene expression [1].

1',4"-Sophorolactone 6',6"-diacetate (2.5-160 μg/mL; 24 h) exhibits dose-dependent inhibition of proliferation in colon cancer cells such as HT29 and HCT116, and also has cytotoxic effects on normal cells [2].

1',4"-Sophorolactone 6',6"-diacetate (100-400 μg/mL; 24-48 h) showed antibacterial activity (MIC=100-400 μg/mL) against oral pathogens such as Streptococcus mutant strains and Actinobacteres naeslundii, and disrupted biofilm formation.

分子式

C₃₄H₅₆O₁₄

分子量

688.8

CAS号

148409-20-5

中文名称

槐糖脂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 200 mg/mL (290.36 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4518 mL	7.2590 mL	14.5180 mL
5 mM	0.2904 mL	1.4518 mL	2.9036 mL
10 mM	0.1452 mL	0.7259 mL	1.4518 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：10% DMSO → 40% PEG300 → 5% Tween-80 → 45% saline

Solubility: ≥ 2.08 mg/mL (3.02 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.02 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂：10% DMSO → 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.02 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.02 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。