Germicidin B is a pyranone antibiotic originally derived from Streptomyces. It acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM. During germination, spores of Streptomyces excrete germicidin B along with other germicidin homologs, which inhibit germination of its own arthrospores. At higher concentrations, germicidin can inhibit the porcine brain Na/K-dependent ATPase (ID = 100 µM) and prevent the germination of the cress L. sativum.
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits hexokinase II with an IC50 of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections.
体外研究
Germicidin B (37 ° C, 10 min) significantly inhibited the activity of purified hexokinase II enzyme, with an IC50 of 7.11 μM.
Germicidin B (0.01-1000 μg/mL) inhibits spore germination of Streptomyces.
分子式
C10H14O3
分子量
182.2
CAS号
150973-78-7
运输条件
Room temperature in continental US; may vary elsewhere.