Cholesteryl Hemisuccinate - CAS:1510-21-0

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Cholesteryl Hemisuccinate (Synonyms:胆固醇琥珀酸单酯)

目录号 : KCM11591 CAS No. : 1510-21-0 纯度 : ≥95%

Data Sheet SDS 产品使用指南

Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.

规格	价格	是否有货
500mg		In-stock
1g		In-stock
5g		In-stock
10 g	询价	In-stock
10 mM * 1 mL in DMSO		In-stock

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生物活性

Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth.

体内研究

Histological and biochemical diagnosis of Cholesteryl hemisuccess (100 mg/kg; ip; single dose AAP) in ICR mice (CD-1) to eliminate cell apoptosis and necrosis induced by AAP (350-500 mg/kg; ip; single dose).

分子式

C₃₁H₅₀O₄

分子量

486.73

CAS号

1510-21-0

中文名称

胆固醇琥珀酸单酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

Ethanol : 25 mg/mL (51.36 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (17.11 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0545 mL	10.2726 mL	20.5453 mL
5 mM	0.4109 mL	2.0545 mL	4.1091 mL
10 mM	0.2055 mL	1.0273 mL	2.0545 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% EtOH → 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.14 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.14 mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL ⽟⽶油中，混合均匀。