BAY u9773 - CAS:154978-38-8

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BAY u9773

目录号 : KCM11658 CAS No. : 154978-38-8 纯度 : ≥95%

Data Sheet 产品使用指南

The biological effects of the cysteinyl leukotrienes (cysLTs, including LTC, LTD, and LTE) are transduced mainly by a pair of 7-transmembrane receptors, CysLT and CysLT BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same IC (20-80 nM) for the inhibition of LT responses in a variety of tissue preparations containing either/or both receptors. In contrast, many of the commercially developed CysLT receptor antagonists (pranlukast or montelukast) antagonize only CysLT receptors. BAY u9773 is thus one of the only available tools for blocking CysLT receptors.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock
500μg		In-stock

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生物活性

BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis.

体外研究

BAY u9773 (10 nM-10 μM; 15 minutes) competitively displaced [³H] leukotriene D4 binding to guinea pig lung membranes, with an average pK_i of 7.0.
BAY-u 9773 (1-10 μM; 30-minute pretreatment) dose-dependently inhibited MCP-1 secretion induced by TvSP and LTC₄ in HMC-1 cells, with the strongest effect observed at 10 μM.
BAY-u 9773 (1-5 μM) dose-dependently inhibited ROS production induced by TvSP and LTC₄ in HMC-1 cells, with significant inhibition observed at concentrations ≥1 μM.
BAY-u 9773 (5 μM) can inhibit TvSP- and LTC₄-induced HMC-1 cell migration, with an inhibition rate of approximately 60%.
BAY-u 9773 (1-5 μM) dose-dependently inhibited degranulation (detected by CD63 expression) induced by TvSP and LTC₄ in HMC-1 cells, with the most potent effect at 5 μM.
BAY-u 9773 can inhibit TvSP-induced p47phox phosphorylation in HMC-1 cells.
BAY-u 9773 can inhibit NF-κB phosphorylation induced by TvSP and LTC₄ in HMC-1 cells.

ELISA Assay

Cell Line:	HMC-1
Concentration:	1 μM; 3 μM; 10 μM
Incubation Time:	30 min pretreatment
Result:	Dose-dependently inhibited TvSP-induced MCP-1 secretion, reducing levels to ~260 pg/mL at 10 μM compared to ~460 pg/mL in untreated TvSP-stimulated cells. Dose-dependently inhibited LTC₄-induced MCP-1 secretion, reducing levels to ~270 pg/mL at 10 μM compared to ~460 pg/mL in untreated LTC₄-stimulated cells.

体内研究

BAY-u 9773 (intravenous injection) can induce dose-dependent bronchoconstriction in anesthetized guinea pigs.

分子式

C₂₇H₃₆O₅S

分子量

472.6

CAS号

154978-38-8

运输条件

Shipping with dry ice.

储存方式

-80°C

纯度： ≥95%

Data Sheet

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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