1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with K values of 7.4 and 16 nM, respectively, compared to a K of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
1,4-PBIT (dihydrobromide) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively.
分子式
C12H18N4S2.2HBr
分子量
444.2
CAS号
157254-60-9
中文名称
1,4-PB-ITU 二氢溴酸盐
运输条件
Room temperature in continental US; may vary elsewhere.