(+)-Oxanthromicin is an enantiomer of the rare Streptomyces metabolite (−)-oxanthromicin. It inhibits K-Ras plasma membrane localization in MDCK cells with an IC value of 62.5 μM.
(+)-Oxanthromicin mislocalizes the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells, and exhibits thereby antitumor efficacy.