Arachidonoyl-2'-Fluoroethylamide (Synonyms:(5Z,8Z,11Z,14Z)-N-(2-氟乙基)-5,8,11,14-二十碳四烯酰胺;2,5-二溴-1,4-苯醌)
目录号 : KCM11890 CAS No. : 166100-37-4 纯度 : ≥98%
Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution adds considerably increased binding affinity for the CB receptor (Ks = 26.7 and 908 nM for CB and CB, respectively). It also contributes additional selectivity, in that binding to CB is decreased relative to AEA. However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme.
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生物活性

Arachidonoyl-2'-Fluoroethylamide is an anandamide analog. Arachidonoyl-2'-Fluoroethylamide has the potential for the research of intraocular hypertension.

体内研究

Arachidonoyl-2'-Fluoroethylamide (0.25% (w/v) 25 µl) induced an initial increase followed by a decrease in intraocular pressure (IOP) in rabbits.

 

Animal Model: 2.6-3.6 kg normotensive pigmented rabbit
Dosage: 25 µl (0.25% (w/v))
Administration: Unilateral ocular administration
Result:
Induced IOP (intraocular pressure) in the treated eye initially increased and then decreased.
 
分子式
C22H36FNO
分子量
349.53
CAS号
166100-37-4
中文名称
2,5-二溴-1,4-苯醌
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2