4-amino-1,8-Naphthalimide - CAS:1742-95-6

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4-amino-1,8-Naphthalimide (Synonyms:4-Aminonaphthalimide;4-氨基-1,8-萘酰亚胺)

目录号 : KCM11987 CAS No. : 1742-95-6 纯度 : ≥95%

Data Sheet SDS 产品使用指南

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

规格	价格	是否有货
10mg		In-stock
50mg		In-stock
100mg		In-stock
250mg	询价	In-stock

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生物活性

4-amino-1,8-Naphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells.

分子式

C₁₂H₈N₂O₂

分子量

212.2

CAS号

1742-95-6

中文名称

4-氨基-1,8-艿二甲酰亚胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO: 1 mg/mL (4.71 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.7125 mL	23.5627 mL	47.1254 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%