4-Methylumbelliferyl Palmitate
(Synonyms:4-甲基伞形基棕榈酸酯;4-甲基伞形酮棕榈酸酯;5-氯-3,4-二氢-1H-2-萘酮)
目录号 : KCM12009
CAS No. : 17695-48-6
纯度 : ≥98%
Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase. 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL). 4-MUP is cleaved by LAL to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. 4-MUP may also be cleaved by other acid lipases. Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP.
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| 分子式 |
C26H38O4
|
| 分子量 |
414.6
|
| CAS号 |
17695-48-6
|
| 中文名称 |
5-氯-3,4-二氢-1H-2-萘酮
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|