AM404 - CAS:183718-77-6

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AM404 (Synonyms:N-(4-羟基苯基)-花生四烯酰胺)

目录号 : KCM12152 CAS No. : 183718-77-6 纯度 : ≥98%

Data Sheet 产品使用指南

AM404 is an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons. AM404 selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis. It inhibits the transport of AEA with an IC of 1 µM in rat neurons and 5 µM in rat astrocytes. In in vivo models, AM404 enhances and prolongs exogenous AEA-induced analgesia at a dose of 10 mg/kg.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg		In-stock

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生物活性

AM404 an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC₅₀ values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC₅₀ value of 7.4 (corresponding to an EC₅₀ of 0.04 μM). Neuroprotective Effect.

体外研究

AM404 reduces C6 glioma cell proliferation with IC₅₀ values of 4.9 μM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide.

Cell Viability Assay

Cell Line:	Rat C6 glioma cells
Concentration:	1, 3, 10 and 30 µM
Incubation Time:	24, 48, 72 and 96 hours
Result:	Produced a concentration-dependent reduction in cell proliferation that was seen with 24 h of exposure to 10 and 30 µM concentrations and after 48 h at 3 µM. The lowest concentration of AM404 tested, 1 µM, produced a significant, albeit small, reduction in cell proliferation at 72 h.

体内研究

AM404 (1-5 mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations.

Animal Model:	Adult male Sprague-Dawley rats (250-300 g)
Dosage:	2.5-10 mg/kg
Administration:	Intraperitoneal (i.p.)
Result:	Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.

分子式

C₂₆H₃₇NO₂

分子量

395.58

CAS号

183718-77-6

中文名称

(5Z,8Z,11Z,14Z)-N-(4-羟基苯基)-5,8,11,14-二十碳四烯酰胺;TRPV1激动剂和环氧合酶COX-1和COX-2抑制剂AM404;N-(4-羟基苯)花生四烯酸酰胺;N-(4-羟基苯基)花生四烯酰胺;对花生四烯酰氨基酚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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