Calpain Inhibitor VI - CAS:190274-53-4

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Calpain Inhibitor VI (Synonyms:钙蛋白酶抑制剂 VI;SJA6017)

目录号 : KCM12248 CAS No. : 190274-53-4 纯度 : ≥95%

Data Sheet SDS 产品使用指南

Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases µ-calpain (calpain-1; IC = 7.5 nM) and m-calpain (calpain-2; IC = 78 nM). It also inhibits cathepsins B and L (ICs = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 µM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

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1mg		In-stock

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生物活性	Calpain Inhibitor VI is a synthesized peptide aldehyde inhibitor of calpain. Calpain Inhibitor VI inhibits purified m-calpain with the IC50 of 80 nM. Calpain Inhibitor VI can be used for the research of cataract.
分子式	C₁₇H₂₅FN₂O₄S
分子量	372.45
CAS号	190274-53-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)