8-iso-15-keto Prostaglandin F2α (Synonyms:8-iso-15-keto PGF2α)
目录号 : KCM12263 CAS No. : 191919-01-4 纯度 : ≥95%
8-iso-15-keto Prostaglandin F (8-iso-15-keto PGF) is a metabolite of the isoprostane 8-iso PGF in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF 8-iso -15-keto PGF is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.
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100μg
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500μg
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1mg
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生物活性

8-iso-15-keto Prostaglandin F2α is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto Prostaglandin F2α mediates a weak relaxation of rats aorta rings at high concentration.

分子式
C20H32O5
分子量
352.47
CAS号
191919-01-4
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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